Poly-L-lactic acid (PLLA) biostimulator is an aesthetic injectable used to stimulate collagen production and restore facial volume lost due to ageing or certain medical conditions. Poly-L-lactic acid (PLLA) is a biocompatible synthetic substance that gradually improves skin thickness and smoothness. Unlike fillers that provide immediate results, this biostimulator works over time, with effects becoming noticeable after a few months and lasting up to two years or more with proper treatment. It is commonly used to treat deep facial wrinkles, folds, and hollow areas.

It originated in France. It was first approved for use in Europe in 1999 for treating facial lipoatrophy (loss of fat beneath the skin), particularly in patients with HIV. The U.S. Food and Drug Administration (FDA) approved it in 2004 for the same purpose, and it has since gained broader approval for cosmetic use to reduce facial wrinkles and folds.

• Collagen Stimulation: It stimulates the body’s collagen production, improving
skin structure and elasticity.
• Volume Restoration: It helps restore facial volume lost due to ageing, illness, or
other conditions, reducing the appearance of sunken cheeks and hollow temples.
• Wrinkle Reduction: By enhancing collagen production and adding volume, it
reduces the appearance of deep wrinkles and folds, such as nasolabial folds (smile
lines).
• Long-Lasting Results: The results are gradual but long-lasting, often persisting
for up to two years or more with proper treatment.
• Natural-Looking Effects: It provides a subtle and natural enhancement, as it
works gradually, allowing for a more natural transition in appearance.
• Non-Surgical Treatment: As a minimally invasive procedure, this treatment
requires no surgery, leading to less downtime and fewer risks compared to surgical
options.