Drug resistance is one of the biggest problems facing humanity. Many scientists have worked hard to identify proteins drug stability and develop new drugs. But still, scientists fail to tackle the problem of drug resistance because they lack the scientific tools to study the resistant proteins in detail.
What is protein?
Proteins are the most critical biomolecules in living beings. They are made up of amino acids that are bonded together. They are the workhorses of living organisms. Proteins are classified based on their function. They perform a particular task in our body.
How are proteins coded?
The genes in a cell store information related to the production of proteins. These genes are encoded in the DNA molecule.
The genes in the genome are arranged linearly. So, each gene in a genome code for a particular protein. The arrangement of the genes in a genome is controlled by order of the genes.
How do we know the sequence of the genes that code for a protein?
Scientists take the help of DNA sequencing technology, and the sequences of these genes are deciphered. The arrangements are then used for the proteins drug resistance.
Proteins are coded by genes and then translated into protein molecules. A unique enzyme does it called a ribosome.
The ribosome consists of rRNA and tRNA. The tRNA contains the codons that code the sequence of the amino acids.
The protein-coding is performed based on the type of amino acid in each position. So, if the position codes for an alpha helix, it should contain only alphabets. The same applies to beta sheets and coils.
What is allostery?
Allostery is how two or more structurally and functionally independent protein domains interact.
It is the process that causes changes in the activity of the protein when one domain binds to the other.
There are two types of allostery.
1. Direct allostery.
2. Indirect allostery.
· In direct allostery, a domain interacts directly with another environment.
· In indirect allostery, the interaction between two parts is indirect and happens through a mediator.
Why is the ensemble allostery model used to study proteins?
The Ensemble Allostery Model is one of the most advanced techniques researchers introduced. It is considered a method of protein simulation. It helps researchers to understand the interactions between amino acids in a protein. This method has revolutionized the field of structural biology.
The ensemble allostery model (EAM) can be used to predict proteins that are resistant to drug resistance. AEM is a method for analyzing proteins that has been shown to predict the resistance of proteins to drug resistance mutations accurately. This method can also be applied to other proteins shown to have different properties due to mutation.
To learn more about proteins drug stability, visit Gain Therapeutics.