Ivermectin Tablet – Uses, Side Effects & Composition

Ivermectin Doses For Humans is a medication that has gained widespread attention for its effectiveness in treating various parasitic infections in humans and animals. It belongs to the class of drugs known as antiparasitic agents and has been used successfully to combat conditions caused by parasitic worms and insects. In this comprehensive guide, we will explore the uses, side effects, composition, dosage, and important considerations regarding Ivermectin Tablet.

Understanding Ivermectin: Uses and Mechanism of Action

Uses in Humans:

Ivermectin is primarily used to treat parasitic infections in humans, including:

• Onchocerciasis (river blindness): A parasitic infection caused by the nematode worm Onchocerca volvulus, transmitted by black flies in certain regions.
• Strongyloidiasis: An intestinal infection caused by the nematode Strongyloides stercoralis.
• Scabies: A skin infestation caused by the mite Sarcoptes scabiei.
• Head lice: An infestation of the scalp by Pediculus humanus capitis.
• Filariasis: A parasitic infection caused by filarial worms transmitted by mosquitoes.
• Rosacea: A skin condition characterized by redness and visible blood vessels on the face.
• Other parasitic infections: Ivermectin may also be used off-label for other parasitic infections under medical supervision.

Mechanism of Action:

Ivermectin works by interfering with the nervous system of parasites, leading to paralysis and death. It binds to specific receptors known as glutamate-gated chloride channels found in nerve and muscle cells of parasites, causing an increase in chloride ion influx and hyperpolarization of the cell membrane. This disrupts the normal functioning of the parasite’s nervous system, leading to its demise.

Composition of Ivermectin Tablet

Ivermectin tablets typically contain the active ingredient Ivermectin, along with inactive ingredients that help form the tablet and improve its stability. The composition may vary slightly depending on the brand or manufacturer, but the primary components include:

Active Ingredient: 

Ivermectin (commonly available in strengths such as 3 mg, 6 mg, or 12 mg per tablet).

Inactive Ingredients: 

These may include microcrystalline cellulose, lactose, povidone, magnesium stearate, colloidal silicon dioxide, and other excipients used as binders, fillers, disintegrants, or lubricants to ensure the tablet’s integrity and facilitate its absorption in the body.

Dosage and Administration

The dosage of Ivermectin Tablet varies depending on the specific condition being treated, the patient’s age, weight, and overall health. It is crucial to follow the prescribed dosage and administration instructions provided by your healthcare provider. Some general guidelines for dosing include:

Onchocerciasis (River Blindness): 

The typical adult dose is a single oral dose of 150 to 200 micrograms per kilogram of body weight, repeated annually if necessary.

Strongyloidiasis: 

The usual adult dose is a single oral dose of 200 micrograms per kilogram of body weight, repeated after 2 weeks if needed.

Scabies: 

For scabies treatment, a single oral dose of 200 micrograms per kilogram of body weight is commonly used, with a second dose recommended after 1 to 2 weeks if necessary.

Head Lice: 

The recommended dose for head lice is a single oral dose based on body weight.

Filariasis: 

The dosage and duration of treatment for filariasis may vary based on the specific filarial species and the severity of infection.

Rosacea: 

Ivermectin may be used topically in the form of a cream or lotion for the treatment of rosacea, with the dosage and application instructions provided by a dermatologist.

It’s essential to take an Ivermectin Tablets as directed, preferably on an empty stomach with a full glass of water, unless otherwise instructed by your healthcare provider. Avoid consuming alcohol or grapefruit juice while taking Ivermectin, as these may interact with the medication and affect its efficacy.

Side Effects of Ivermectin Tablet

While Ivermectin is generally considered safe and well-tolerated, it can cause side effects in some individuals. Common side effects may include:

Gastrointestinal Symptoms: 

These may include nausea, vomiting, diarrhea, abdominal pain, or bloating. Taking Ivermectin with food may help reduce gastrointestinal discomfort.

Dizziness or Lightheadedness: 

Some individuals may experience dizziness, lightheadedness, or a spinning sensation (vertigo) after taking Ivermectin.

Fatigue or Weakness: 

Feelings of tiredness, weakness, or malaise may occur, particularly with higher doses or prolonged use.

Skin Reactions: 

Rarely, Ivermectin may cause skin reactions such as rash, itching, hives, or swelling of the face, lips, or tongue. Discontinue use and seek medical attention if you experience severe skin reactions.

Neurological Symptoms: 

In rare cases, Ivermectin may cause neurological symptoms such as headache, drowsiness, tremors, confusion, or seizures. Seek medical advice if you experience these symptoms.

It’s important to note that serious side effects with Ivermectin are rare but possible, especially with higher doses or in individuals with underlying health conditions. If you experience any concerning or persistent side effects, contact your healthcare provider for evaluation and guidance.

Precautions and Considerations

Before taking an Ivermectin Tablet, consider the following precautions and considerations:

Pregnancy and Lactation:

 Ivermectin should be used with caution in pregnant or breastfeeding women, as safety data in these populations are limited. Consult your healthcare provider for guidance.

Children and Elderly: 

Dosage adjustments may be necessary for children or elderly individuals based on age, weight, and health status. Follow pediatric or geriatric dosing guidelines provided by your healthcare provider.

Liver or Kidney Impairment: 

Individuals with liver or kidney impairment may require dosage adjustments or close monitoring while taking Ivermectin. Inform your healthcare provider about any existing medical conditions.

Drug Interactions:

 Ivermectin may interact with certain medications, supplements, or herbal products. Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and supplements.

Travel Considerations: 

Ivermectin may be used as a preventive treatment for certain parasitic infections in travelers to endemic regions. Follow travel health recommendations and consult a healthcare provider for appropriate prophylactic use.

Conclusion: Using Ivermectin Tablet Safely and Effectively

Ivermectin Tablet is a valuable medication used to treat various parasitic infections in humans. By understanding its uses, composition, dosage, side effects, and precautions, individuals can use Ivermectin safely and effectively under the guidance of a healthcare provider. It is essential to follow prescribed dosing instructions, monitor for side effects, and seek medical advice if needed. With proper use and adherence to healthcare recommendations, Ivermectin can help combat parasitic infections and improve overall health and well-being.